Basic Organization Information
Juvenile Bipolar Research Foundation, Inc.
- Also Known As:
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JBRF
- Physical Address:
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Maplewood, NJ
07040
- EIN:
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16-1612095
- Web URL:
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www.jbrf.org
- Blog URL:
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www.jbrf.org
- NTEE Category:
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H Medical Research
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H98 Pediatrics Research
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F Mental Health, Crisis Intervention
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F70 Mental Health Disorders
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G Disease, Disorders, Medical Disciplines
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G99 Diseases, Disorders, Medical Disciplines N.E.C.
- Year Founded:
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2001
- Ruling Year:
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2002
- How This Organization Is Funded:
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Private donors
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Mission Statement
The Juvenile Bipolar Research Foundation actively promotes and supports scientific research focused on identifying the biological cause of early onset bipolar disorder. JBRF is the first and only non-profit foundation dedicated solely to targeted, science-based research to determine the cause of and treatment for this disorder.
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Impact Summary from the Nonprofit
JBRF has the largest source of symptom data in the world from children affected by bipolar disorder. Research based on our data has resulted in:
JBRF developed diagnostic screening instruments to meet the need for the early identification of bipolar disorder in children:
The Child Bipolar Questionnaire (CBQ) is a rapid, low-cost screening tool that has demonstrated a high degree of accuracy predicting various phenotypes of bipolar disorder as well as ADHD.
The Jeannie/Jeffrey Illustrated Interview for Children is a screening instrument that makes possible the direct reporting of symptoms by a young child. The comic-strip style illustrations promotes the child's willingness and ability to reveal mood states, fears, suicidal thoughts and/or hallucinations.
The : A dimensional approach to screening for pediatric bipolar disorder, January 2011, explores the efficacy of the CBQ.
The results of a JBRF study focused on establishing guidelines for differentiating early-onset bipolar disorder from ADHD were published in the , (Jan 2011). The data from neuropsychological testing of 33 children with bipolar disorder and 22 children with ADHD-only demonstrated specific differences in the neuropsychological profiles. The MRI imaging on the subject children with bipolar disorder revealed a consistent abnormality in the amygdala.
Leadership
Ms. Inger M. Sjogren
Term:
Since
Aug
2008
Profile:
Ms. Sjogren has served as the Executive Director of JBRF since August 2008. She studied Economics at l’Université de Génève and graduated from Smith College in 1990 with a B.A. in Developmental Economics. After gaining finance experience by working in the venture capital industry, Ms. Sjogren attended Columbia University’s Graduate School of Business where she was elected to the post of Vice President on the student government. Upon earning her M.B.A. in Finance, she joined UBS where she focused on structuring asset-backed securities and off-balance sheet financing. She is a sprint-triathlete and mother of three children.
Leadership Statement:
The research emphasis and direction of JBRF is unique. Rather than rely upon theoretical consensus, this foundation has been pushing past the philosophical debate that has stagnated research into this disorder for so many years. We have applied our resources to supporting the most promising and cutting-edge research.
Focus on identifying the physiology that causes early-onset bipolar disorder calls our research to be "hands-on" rather than text book oriented. JBRF's research has brought the orexigenic neuropeptide pathway into consideration as a facilitator for the disorder. Affected by this pathway are blood pressure, fear response, sleeping, eating, reward seeking...among many others. A disruption in this pathway can explain the broad range of symptoms that plague many children who are diagnosed as having bipolar disorder.
Our investigators have discovered that thermal regulation plays an important role in the expression of behaviors/symptoms experienced by our subject population. We have completed one study focused on thermoregulation - and findings are provocative. Investigators will continue to pursue this line of research.
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Program:
Treatment Clinical Trial
- Budget:
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$451,225
- Category:
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Mental Health, Substance Abuse
- Population Served:
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Children Only (5 - 14 years)
Program Description:
Research conducted through JBRF has defined a behavioral profile which describes those children on the bipolar spectrum who are most severely affected by the illness. This profile is called the Fear of Harm (FOH) phenotype.
Since Oct. 2008, we have conducted a pilot study in which a drug called ketamine has been used to treat the symptoms of FOH. All of the children and young adults who participated in that pilot study have experienced a continuous elimination or significant reduction of the primary symptoms of the condition.
The Ketamine Clinical Study has been approved by Federal Drug Administration (FDA).
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Program:
Whole Genome Sequencing Study
- Budget:
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$170,000
- Category:
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Diseases, Disorders & Medical Disciplines
- Population Served:
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Children and Youth (infants - 19 years.)
Program Description:
The focus of this study is to identify the rare dysfunctional genetic variants that are linked to bipolar disorder. The study will be conducted at the Albert Einstein College of Medicine and will be done using state of the art sequencing technology. Using DNA from a diagnosed child and their family members, the DNA will be put through whole genome (or exome) sequencing as a tool for abnormal gene discovery. Identification of suspect genetic variants will give us the tool to make definitive diagnosis of bipolar disorder cases.
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Evidence of Impact
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Organizational Strengths
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Areas for Improvement
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