FOCUSED ULTRASOUND FOUNDATION

The Focused Ultrasound Foundation aims to improve the lives of millions of people around the world with serious medical disorders by accelerating the development and adoption of focused ultrasound--an early-stage, noninvasive therapeutic technology with the potential to transform the treatment of many medical disorders by serving as an alternative to surgery and radiation.

To begin, we analyzed the steps in the process and the organizations involved in the evolution of focused ultrasound from concept to widespread adoption as a standard of care, identifying the bottlenecks or impediments to progress. Then we developed a portfolio of programs designed to overcome the impediments, shortening the time from laboratory research to patient treatment.

The Foundation's activities include:
• Research Programs:
- Brain (Alzheimer's, Parkinson's, Dystonia, Tumors, Epilepsy, Depression, Blood Brain Barrier, and Technology Development)
- Pediatric indications (Osteoid Osteoma, Soft Tissue Tumors)
- Musculoskeletal (Back pain, Knee Osteoma)
- Oncology (Breast Cancer, Immunotherapy, Liver & Pancreatic)
• Scholars program
• Centers of Excellence
• Bi-annual Symposium

To advance our agenda, we positioned the Foundation at the nexus of the biomedical innovation ecosystem, using as our currency our passion and enthusiasm for the potential of this technology, information, and financing.

We've created an incredible force to drive the field forward by amalgamating individuals, including our donors, our Board of Directors, our counsel and the team of 20+ individuals who work for the foundation, who share extensive experience and expertise in finance, medicine, engineering, business, technology and philanthropy.

The Foundation has contributed materially to the rapidly growing body of knowledge about focused ultrasound through our research programs. This has resulted in the development of a variety of new treatments for life-threatening or disabling disorders that are in various stages of research and development. Our efforts have resulted in a host of new collaborations and partnerships between research laboratories in academia, manufacturers, FDA, etc.

While our efforts have resulted in identification of a number of new mechanisms by which focused ultrasound effects tissue , enabling the development of a rapidly growing number of treatments for a variety of indications, commercial success which would lead to widespread utilization of the technology has thus far remained elusive. However, progress in biomedical research and technology development occurs nonlinearly and it is our assessment that we are at the inflection point of the curve and the next several years will see the technology taking off.