PLATINUM2023

The Human Immunome Project

Decoding the Human Immune System

Mission

The Human Immunome Project is a non-profit public-private partnership with the mission to accelerate the development of vaccines and immunotherapies against major infectious diseases and cancers by decoding the human immune system. HIP has set a long term goal of the development of an AI model of the human immunome.

Notes from the nonprofit

The Human Immunome Project is in the process of drafting a strategic plan.

Ruling year info

2015

President and CEO

Wayne Koff

Senior Vice President and Chief Strategy Officer

Ted Schenkelberg

Main address

209 West 29th Street, Suite 6178

NEW YORK, NY 10001 USA

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EIN

47-2364966

NTEE code info

Research Institutes and/or Public Policy Analysis (H05)

IRS filing requirement

This organization is required to file an IRS Form 990 or 990-EZ.

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Communication

Programs and results

What we aim to solve

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Our programs

SOURCE: Self-reported by organization

What are the organization's current programs, how do they measure success, and who do the programs serve?

AI Modeling Initiative

For the first time ever, scientists at the Human Immunome Project are combining systems biology with artificial intelligence to understand one of the greatest remaining frontiers of human health, the human immune system.

Modeled after the Human Genome Project, which has transformed biomedical research, the Human Immunome Project (formerly known as the Human Vaccines Project) is seeking to transform how we fight our most devastating diseases by unlocking the mechanisms of human immunity — accelerating the development of new vaccines, diagnostics, and treatments.

Population(s) Served
People with diseases and illnesses
People with diseases and illnesses

Every year 3 million children are stillborn, 800,000 new-borns die from infection and 15 million babies are born dangerously pre-term. That’s more than 1 in every 10 babies robbed of a healthy life. This is not just a problem in low- and middle-income countries. Despite the scientific leaps we’ve made, these statistics haven’t changed in decades. Cause(s) of pre-term birth is not well understood, and there are currently no vaccines, diagnostics, or therapeutics for prevention and control.

The BORN STRONG Initiative is an ambitious series of research projects, focused on finding effective ways to strengthen a mother’s immune system in order to positively impact her baby’s immune resilience.

Population(s) Served
Women and girls
Infants and toddlers

The Michelson Prizes: Next Generation Grants are $150,000 research grants given annually to support promising researchers who are applying disruptive concepts and inventive processes to advance human immunology, vaccine discovery, and immunotherapy research for major global diseases. research aimed at tackling the current roadblocks that exist in human vaccine development and expanding our limited understanding of key immune processes that are fundamental to successful vaccine and immunotherapy development. The Michelson Prizes are awarding research that is highly innovative and impactful, with the potential to be applied across many diseases.

Population(s) Served

The Human Immunomics Initiative (HII) is a joint initiative partnering the Harvard T.H. Chan School of Public Health and the Human Vaccines Project to create the world’s premier immunology initiative that aims to revolutionize the understanding of the human immune system and accelerate the creation of effective vaccines, with a specific focus on aging populations. The HII will merge large-scale cohort studies with advances in systems biology, bioinformatics, and artificial intelligence (AI) to determine the rules of engagement for effective immunity in aging populations aiming to answer core questions of aging such as: Why do some people get disease as they age, while others do not? And how do we engineer aging immune systems to better fight disease?

Population(s) Served
People with diseases and illnesses
People with diseases and illnesses

Where we work

Our results

SOURCE: Self-reported by organization

How does this organization measure their results? It's a hard question but an important one.

Number of research studies conducted

This metric is no longer tracked.
Totals By Year
Type of Metric

Output - describing our activities and reach

Direction of Success

Holding steady

Context Notes

The HIP and its partners are undertaking some of the most in-depth vaccine studies yet conducted to understand how such vaccines protect, which vaccines work best for which populations, and how to imp

Total number of grants awarded

This metric is no longer tracked.
Totals By Year
Type of Metric

Output - describing our activities and reach

Direction of Success

Increasing

Context Notes

The $150,000 research grants are awarded each year to early career innovators who apply disruptive research concepts to advance human immunology, vaccine discovery, and immunotherapy globally.

Our Sustainable Development Goals

SOURCE: Self-reported by organization

Learn more about Sustainable Development Goals.

Goals & Strategy

SOURCE: Self-reported by organization

Learn about the organization's key goals, strategies, capabilities, and progress.

Charting impact

Four powerful questions that require reflection about what really matters - results.

The Human Immunome Project is an independent global non-profit organization dedicated to developing AI based models the immune system to rethink research across diseases, and ultimately extend and enhance the healthy lifespan of 8 billion human beings.

The Human Immunome Project is compiling the biggest dataset of biomedicine at a population scale. We will use this data to create the first AI model of the human immune system, which will help us speed up the testing process and make the development of vaccines and treatments faster, cheaper and more effective.

The goal is to collect detailed information on the complex network of genes, proteins, cells, and molecules that constitute the human immunome, and to do this for diverse, global populations over time. Then, by harnessing the power of AI, scientists can crunch these data to generate models of the human immune system. These models can then be used to develop new vaccines and treatments where there none, to protect our populations must vulnerable to disease, and accelerate research across infectious and non-communicable diseases.

In the work that it does, and how it does that work, HIP is committed to diversity, equity and inclusion in all facets of our organization and work and believe it is essential to our achieving our goals. Our DEI commitment and effort encompasses:

• Create AI models that reflect human immunological diversity
- scientific priorities and ethical inclusion in research
• advisory and Board committees
• conferences hosted by HVPI
• selection of vendors and consultants that HVPI engages
• workplace hiring of staff and fellows.

Our commitment is essential to our global mission and vision of a world where every person has a chance to enjoy a longer and healthier life.

HIP works with the top researchers and scientific institutions across the world to carry out its mission. Through our global consortium we enable leading researchers and scientists around the world to work together in designing, implementing, and analyzing outputs from scientific studies. We also partner with leading academic institutions to study specific aspects of immunity and ensure comprehensive data analytics and management.

We have open-sourced the first sequencing of the human immune system, used machine learning to predict who will and will not respond to vaccination, and established one of the world's leading scientific consortia and immunology-based research networks. Our network has published seminal studies on the human immunome in high-profile journals, and we’ve made our data publicly available for additional research. HIP has also become a highly impactful advocacy organization, helping to catalyze new ways of working and thinking for human immunology, one of the great frontiers of biomedicine.

In 2022, the Human Immunome Project held a Summit and is now working to develop and implement a strategic plan for creating AI models of the human immunome. The strategic planning process will include follow-on summits held in Europe, Asia, and Africa. At these meetings, participants will delve deeper into some of the key questions related to this initiative, including defining the grand scientific challenges that could be accomplished in the next five years.

Over the next several years, HIP will embark on launching a series of Grand Challenges to solve core problems in human immunology, and lay the foundation for increasingly powerful models of the human immunome.

Financials

The Human Immunome Project
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Operations

The people, governance practices, and partners that make the organization tick.

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Connect with nonprofit leaders

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The Human Immunome Project

Board of directors
as of 01/31/2023
SOURCE: Self-reported by organization
Board chair

Julie Bishop

Board leadership practices

SOURCE: Self-reported by organization

GuideStar worked with BoardSource, the national leader in nonprofit board leadership and governance, to create this section.

  • Board orientation and education
    Does the board conduct a formal orientation for new board members and require all board members to sign a written agreement regarding their roles, responsibilities, and expectations? Yes
  • CEO oversight
    Has the board conducted a formal, written assessment of the chief executive within the past year ? Yes
  • Ethics and transparency
    Have the board and senior staff reviewed the conflict-of-interest policy and completed and signed disclosure statements in the past year? Yes
  • Board composition
    Does the board ensure an inclusive board member recruitment process that results in diversity of thought and leadership? Yes
  • Board performance
    Has the board conducted a formal, written self-assessment of its performance within the past three years? Not applicable

Organizational demographics

SOURCE: Self-reported; last updated 1/31/2023

Who works and leads organizations that serve our diverse communities? Candid partnered with CHANGE Philanthropy on this demographic section.

Leadership

The organization's leader identifies as:

Race & ethnicity
White/Caucasian/European
Gender identity
Male, Not transgender (cisgender)

The organization's co-leader identifies as:

Race & ethnicity
White/Caucasian/European
Gender identity
Male

Race & ethnicity

Gender identity

 

Sexual orientation

Disability

Equity strategies

Last updated: 01/31/2023

GuideStar partnered with Equity in the Center - an organization that works to shift mindsets, practices, and systems to increase racial equity - to create this section. Learn more

Data
  • We ask team members to identify racial disparities in their programs and / or portfolios.
  • We employ non-traditional ways of gathering feedback on programs and trainings, which may include interviews, roundtables, and external reviews with/by community stakeholders.
  • We disaggregate data by demographics, including race, in every policy and program measured.
Policies and processes
  • We seek individuals from various race backgrounds for board and executive director/CEO positions within our organization.
  • We have community representation at the board level, either on the board itself or through a community advisory board.
  • We engage everyone, from the board to staff levels of the organization, in race equity work and ensure that individuals understand their roles in creating culture such that one’s race identity has no influence on how they fare within the organization.