National Pediatric Cancer Foundation, Inc.

Rise Up For A Faster Cure

aka Pediatric Cancer Foundation   |   TAMPA, FL   |  www.nationalpcf.org

Mission

The National Pediatric Cancer Foundation is a nonprofit organization dedicated to funding research to eliminate childhood cancer. Our focus is to find less toxic, more targeted therapies through a unique collaborative research initiative and partnership with top hospitals across the country.

Ruling year info

1992

Chief Executive Officer

Mr. David Frazer

Main address

5550 W EXECUTIVE DR STE 200

TAMPA, FL 33609-1040 USA

Show more contact info

Formerly known as

Pediatric Cancer Foundation

EIN

59-3097333

NTEE code info

Cancer Research (H30)

Fund Raising and/or Fund Distribution (E12)

Pediatrics Research (H98)

IRS filing requirement

This organization is required to file an IRS Form 990 or 990-EZ.

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Communication

Blog

Programs and results

What we aim to solve

SOURCE: Self-reported by organization

Pediatric cancer is the deadliest disease amongst children. 43 children a day are diagnosed with cancer and approximately 40,000 are battling various forms of the disease each year. Compounding the issue, patients are often treated with adult medications. As a result, 95% experience lasting side effects from the toxicity of these drugs which can plague survivors into adulthood. The National Pediatric Cancer Foundation focuses on funding research for less toxic, more targeted cancer treatment for kids. NPCF created a unique collaborative network of doctors and researchers at top hospitals across the nation to fast track treatments for kids who have not experienced positive results under the standard treatment protocols.

Our programs

SOURCE: Self-reported by organization

What are the organization's current programs, how do they measure success, and who do the programs serve?

Sunshine Project

The Sunshine Project is a novel collaborative approach that is accelerating the development of new drugs and therapies leading to the prevention and cure of pediatric cancers. In developing this collaboration, the Foundation has brought together leading investigators and institutions to drive the process of finding a cure.

Through the establishment of the Sunshine Project, the National Pediatric Cancer Foundation has developed a business model unlike any other in the field of pediatric cancer research. Capitalizing on the strengths of researchers from a variety of scientific fields, we have streamlined the process of protocol development in the hopes of delivering more personalized medicine to children with cancer. Investigators are performing three vital phases of research simultaneously: Basic Science, Translational Research and Clinical Trials. These major research components not only allow doctors to identify new agents in fighting cancer but also help researchers to understand the cancer cell's response to the drug.

Through the Sunshine Project, the Foundation has launched several clinical trials and many new combinations of drugs and therapies have been, and continue to be tested. The treatment options being discovered through the Sunshine Project are bringing great promise for children who have not experienced positive results under the standard treatment protocol.

In 2013, NPCF also opened the first pediatric blood and tissue banking program in Florida to further personalized medicine for children with cancer. As part of this program, doctors can store and study a patient's tumor to potentially identify an Achilles heel which may lead to a type of therapy specific to that child. Studies may also lead to a better understanding of what changes cause specific cancers. This trial has proven successful with adult cancer patients, but this is the first time pediatric banking has been made available in Florida.

The National Pediatric Cancer Foundation's Research Laboratory at Moffitt Cancer Center was also opened in 2013. The focus of the NPCF lab is to create a system to rapidly evaluate many agents and combinations of agents which can then immediately be translated into clinical trials. We maximize the translational potential of the results by studying agents at clinically relevant doses across multiple childhood tumor cell lines for several prevalent forms of pediatric sarcomas. There have been multiple combinations for osteosarcoma already published and more combinations are currently being investigated.

Population(s) Served
Children and youth

Assists advanced cancer patients (children under the age of 18) with treatment related costs. It provides grants for assistance with medicine, transportation to/from treatment, insurance co-pays or out of pocket costs, and medical supplies.

Population(s) Served
Children and youth

The National Pediatric Cancer Foundation’s Educational Toolkit is a first-of-its-kind educational resource for patients and families, an initial introduction to the disease state.

The toolkit was developed in partnership with oncology professionals, caregivers, and past patients. Standards of care were evaluated and reviewed by current practicing oncology doctors and nurses and are determined to be the best evidence-based practices.

This toolkit is distributed through NPCF’s research hospitals and the networks of NPCF’s non-profit partners.

Organizations may contact NPCF to inquire about this resource for their patient population.

Population(s) Served
Children and youth

The National Pediatric Cancer Foundation (NPCF) annually engages hundreds of families via our awareness and development programs. Many of these patients seek critical information related to their disease management. Although most hospitals provide a liaison for these patients, families stress the need for an external opinion and information. The NPCF is here to provide key information based on science. This program is a key bridge between the science and education that NPCF provides via its mission.

Population(s) Served
Children and youth
Families

Where we work

Awards

4 star 2012

4 Star Charity Navigator

4 star 2011

4 Star Charity Navigator

4 stars 2013

4 Star Charity Navigator

4 Stars 2014

4 Star Charity Navigator

Top 10 Charities to Watch 2014

1 of "Top 10 Charities to Watch" by Charity Navigator

Certification by WGA 2015

Wise Giving Alliance

4 Stars 2015

4 Star Charity Navigator

4 Stars 2016

4 Star Charity Navigator

4 Stars 2017

4 Star Charity Navigator

100% Rating for Financial Health & Transparency 2017

Charity Navigator

4 stars 2018

4 Star Charity Navigator

100% Rating for Financial Health & Transparency 2018

Charity Navigator

4 Stars 2019

Charity Navigator

100% Rating for Financial Health & Transparency 2019

Charity Navigator

Affiliations & memberships

Better Business Bureau Wise Giving Alliance - Organization 2017

Better Business Bureau Wise Giving Allicance 2018

Better Business Bureau Wise Giving Alliance 2019

Better Busness Bureau Wise Giving Alliance 2020

Our results

SOURCE: Self-reported by organization

How does this organization measure their results? It's a hard question but an important one.

Number of clinic sites

This metric is no longer tracked.
Totals By Year
Population(s) Served

Children and youth

Related Program

Sunshine Project

Type of Metric

Output - describing our activities and reach

Direction of Success

Holding steady

Context Notes

NPCF currently partners with pediatric oncologists and researchers from top hospitals across the country. To see a current list, please visit: https://nationalpcf.org/our-research/our-hospitals/

Our Sustainable Development Goals

SOURCE: Self-reported by organization

Learn more about Sustainable Development Goals.

Goals & Strategy

SOURCE: Self-reported by organization

Learn about the organization's key goals, strategies, capabilities, and progress.

Charting impact

Four powerful questions that require reflection about what really matters - results.

We accomplish our mission through our research initiative, the Sunshine Project (SP). SP is an innovative collaboration among more than 20 hospitals nationwide. The need for new therapies for children battling cancer is dire. Currently, cancer remains the leading cause of death by disease among children under the age of 15 in the United States. Worldwide, more than 160,000 children are diagnosed with cancer each year. Childhood cancer occurs regularly, randomly, and spares no ethnic group, socioeconomic class, or geographic region. In the United States, the incidence of cancer among adolescents and young adults is increasing at a greater rate than any other age group, except those over 65 years. Survival comes with a cost. Ninety five percent of pediatric cancer survivors develop at least one chronic health condition because treatments are so harsh. That is why our Sunshine Project exists – to find less toxic, more targeted therapies for children battling cancer.

The Sunshine Project's current research initiatives are:
Clinical Research: SP has various open initiatives at present: various Sarcoma Trials, a Brain Tumor trial for newly diagnosed pediatric high-grade gliomas, Phase 1 trial for patients with relapsed or refractory Ewing sarcomas, and various non treatment trials.
Total Cancer Care Program: Opened first pediatric blood and tissue banking program in Florida.
Translational Research: Our Sunshine laboratory at Moffitt Cancer Center has performed drug screenings against 6 different diseases that impact children and adolescents. They have tested over 180 unique, individual agents so far, at multiple concentrations. For these individual agents, they have screened over 300 combinations of agents at various concentrations based on published references. In addition to the important task of finding new treatment regimens for these diseases, we use cutting edge technology available to investigate the molecular biological mechanisms underlying these cancers.

NPCF Strategic Plan -
Goal 1: Grow efficient/ effective / ROI core programs and services
Goal 2: Deliver a strong and visible brand that engages key audiences in the fight against pediatric cancer.
Goal 3: Provide comprehensive fundraising models that bolster the NPCF brand and utilizes personalized engagement with donors of all types and sources.
Goal 4: Enhance and strengthen NPCF's infrastructure and top quality workforce to support program and services.

Strategic Priority #1: Grow efficient / effective ROI core programs and services.
Strategic Priority #2: Develop a strong and visible brand that engages key audiences in the fight against pediatric cancer
Strategic Priority #3: Develop comprehensive fundraising models that bolster the NPCF brand and utilizes personalized engagement with donors of all types & sources, with the objective of continually moving them to more significant philanthropic commitments.
Strategic Priority #4: Continually develop and strengthen NPCF's infrastructure and top-quality workforce to support programs and services

Priority #1: A. Sunshine Project- enhance research through funding and stakeholders B. "Education & Awareness" - continue platform that provides relevant disease and system content for patients and families impacted by pediatric cancer. C. Continue providing "Safety Net" program that provides financial support for patients and families battling cancer. D Cause Campaigns - continue the creative , entrepeneurial spirit and execution.
Priority #2: A. Continue to build brand as nation's most effective nonprofit fighting pediatric cancer and helping people live healthier lives through research, educations and awareness. B )Increase constituent's engagement across all channels, including digital platforms, events, and public relations.
Priority #3: A. Consistent evaluation of fundraising models and relationships and explore possible new partnership opportunities. B. Identify and expand legacy donors. C. Identify new areas of support outside the cancer community. D. Build strategic partner engagement relationships to convert customers and other partners to donors.
Priority #4: A. Continue to recruit / develop top quality work force through continuous improvement of a HR system that incorporates recruitment, training, competitive compensation, recognition, performance measurement and succession planning. B. Ensure efficient systems and office operations and alignment with changing management strategies and objectives. C. Sustain and maintain CRM & IT infrastructure to support and advance all organizational priorities in a timely and efficient manner.

Not only does NPCF have multiple open trials and studies but we have
1. finalized and published the following trials:
a.Phase I Trial of Dose Escalation of Metformin in Combination with Vincristine, Irinotecan, and Temozolomide in Children with Relapsed or Refractory Solid Tumors
b. Combining ESR1 expression/activation with gp130 inhibition in osteosarcoma.
c. Relapsed Acute Lynphoblastic Leukemia Trial
d. Phase 1 Topotecan and Sorafenib in Relapsed or Refratory Solid Tumors

2. During this past year, The NPCF Sunshine Project Research Laboratory at Moffitt Cancer Center -
a. Has performed drug screening against 6 different diseases that impact children and adolescents – Alveolar Soft Part Sarcoma (ASPS), Ewing Sarcoma, Malignant Peripheral Nerve Sheath Tumors (MPNST), Osteosarcoma, Rhabdomyosarcoma (RMS), and Leiomyosarcoma. Altogether, we have thus far characterized two ASPS cell lines, four Ewing Sarcoma cell lines, five MPNST cell lines, six Osteosarcoma cell lines, four RMS lines, and two leiomyosarcoma lines, for a total of 23 individual sarcoma models.
b. We have tested over 180 unique, individual agents so far, at multiple concentrations. From these individual agents, we have screened over 300 combinations of agents at an average of 25 different concentrations for each combination. In other words, we have obtained data for over 7500 different two-drug regimens altogether across these 6 diseases.
c. In addition to the important task of finding promising new treatment regimens for these diseases, we use cutting edge technology available at our Molecular Genomics Core to investigate the molecular biological mechanisms underlying these cancers.

3. Created a very qualified and reputable clinical trial Oversight Committee to increase the safety and reporting mechanism for Sunshine Project Trials.

4. Since 2010, we have conducted ten successful Annual Retreats for doctors, coordinators, NPCF Board members and donors to discuss new trials and research projects, as well as opening avenues of communication and trust.

5. During the past years National Pediatric Cancer Foundation has invested more than $26 million into our CORE program activities.

6. 88% of our operating expenses are directly related to our program services.

Financials

National Pediatric Cancer Foundation, Inc.
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Operations

The people, governance practices, and partners that make the organization tick.

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National Pediatric Cancer Foundation, Inc.

Board of directors
as of 5/12/2022
SOURCE: Self-reported by organization
Board co-chair

Mr. Alex Sullivan


Board co-chair

Mr. Chad Harrod

Board leadership practices

SOURCE: Self-reported by organization

GuideStar worked with BoardSource, the national leader in nonprofit board leadership and governance, to create this section.

  • Board orientation and education
    Does the board conduct a formal orientation for new board members and require all board members to sign a written agreement regarding their roles, responsibilities, and expectations? Yes
  • CEO oversight
    Has the board conducted a formal, written assessment of the chief executive within the past year ? Yes
  • Ethics and transparency
    Have the board and senior staff reviewed the conflict-of-interest policy and completed and signed disclosure statements in the past year? Yes
  • Board composition
    Does the board ensure an inclusive board member recruitment process that results in diversity of thought and leadership? Yes
  • Board performance
    Has the board conducted a formal, written self-assessment of its performance within the past three years? Yes

Organizational demographics

SOURCE: Self-reported; last updated 10/07/2020

Who works and leads organizations that serve our diverse communities? GuideStar partnered on this section with CHANGE Philanthropy and Equity in the Center.

Leadership

The organization's leader identifies as:

Race & ethnicity
White/Caucasian/European
Gender identity
Male, Not transgender (cisgender)
Sexual orientation
Heterosexual or Straight
Disability status
Person without a disability

Race & ethnicity

No data

Gender identity

No data

 

No data

Sexual orientation

No data

Disability

No data